Suppositories are bullet-shaped, solid preparations that are designed so that they can be inserted into the anus. They are generally made up of vegetable oil in a solid form that carries the medicine. These suppositories dissolve at the body temperature and spread over the rectum lining. Here are the common compounds for suppository preparations that manufacturers of suppositories should know about. But moving ahead, let’s understand the types of preparations available.
Rectal Preparations
These preparations generally include solutions, ointments, and suppositories. Suppositories are the dosage forms in various sizes and shapes of solid forms that, after dissolving in secretions of the mucous membrane, meltdown at the level of body temperature for the systematic and local release of medication. Rectal preparations are used to exert the systematic effect that helps avoid hepatic gastrointestinal or metabolism degradation. It is used if it is impossible to use oral administration because of difficulty in swallowing or vomiting problem. And, diclofenac suppositories are used for swelling, joint stiffness, and pains caused due to arthritis.
Vaginal Preparations
It includes powders, aerosol foams, solutions, creams, ointments, tablets, and suppositories. Vaginal pessaries or suppositories are used as bacterial antibiotics, hygiene antiseptics for females, contraceptives, or for restoring the mucosa. They generally come in oval shapes with a weight ranging from 3 to 5 grams.
Preparation Compounds
• Suppository Bases
These should be inert, non-irritating, non-toxic, and suitable for all active ingredients. They are easily formed with the methods of molding or compression. Suppository bases are very important for the extent and rate of medication releases and can be characterized by their physical properties and composition.
• Water-soluble or Miscible Bases
These contain polymers of polyethylene glycol or glycerinated gelatin. When they dissolve in the body fluids, the drug should be released. There is no need for the body temperature to melt it, the suppositories can be made to melt at higher degrees. Hence, they are stored at room temperature.
• Oleaginous Bases
These including the obroma oil that exhibits polymorphism and would lead to the melting of suppositories rendering them non-usable. Mixing synthetic triglycerides helps prevent polymorphism due to the presence of hydrogenated vegetable oils.
Thus, this knowledge of bases and compounds will help the manufacturer of suppositories prepare better products like diclofenac suppositories and more.
Suppositories Manufacturer Nigeria 